Dante's Inferno: An Animated Epic

Nessus in the direct-to-DVD animated film Dante's Inferno: An Animated Epic (a tie-in to the video game Dante's Inferno) was a centaur who resided around the Phlegethon, the boiling river of blood that comprised the first part of the Seventh Circle of Hell. She was a friend of Virgil who allowed he and Dante to ride across the treacherous river on her back. She is loosely based on a centaur by the same name from Greek mythology who appeared in Dante Alighieri's original Divine Comedy.