Family Guy

Family Guy is an adult animated sitcom created by Seth MacFarlane that acts as a rival to The Simpsons, of which it carries a similar concept but different style of humor to. It lasted for a few years beginning in 1999 before cancellation, mainly due to controversy, but due to its following FOX brought it back on the air in 2005. It is now part of their Animation Domination block.

Peter's Two Dads
Season 5, Episode 10 Airdate: February 11, 2007

Stewie's recollection of Lois hitting him features Lois with massively muscular arms to brute beating out of him.

Baby, You Knock Me Out
Season 9, Episode 5 Airdate: November 14, 2010 Deirdre is a fearsome boxer who relies on brute force to knock down her opponent. She was known well for being a formidable boxer since she had murdered some of her opponents in cold blood. In her competition against Lois, Deirdre was able to bring Lois to her limits and nearly killed her. She looks like a bodybuilder and she didn't flex. She was boxing against Lois Griffin.

Peter's Sister
Season 14, Episode 6 Airdate: November 15, 2015 Karen Griffin is the half-sister of Peter Griffin; she has been first and only appeared in this episode and a pro-wrestler with the stage name "Heavy Flo" also flex and pose.

Peter & Lois' Wedding
Season 18, Episode 6 Airdate: November 10, 2019 Two generic female bodybuilders arm-wrestling

Connie's Celica
Season 18, Episode 10 Airdate: January 5, 2020 Later at home, Peter finds himself the victim of the sexual desires of a prison-buffed Lois.

Mister Act
Season 20, Episode 11 Airdate: January 9, 2022

Lois tries on exercise equipment to become ripped and muscular even having cheekbones. Stewie is attracted to Lois' new masculine physique. by the end, Lois stops working out, and then she's back to the normal of her old body.

Family Guy: The Quest for Stuff
Jailhouse Meg flexes her biceps in Family Guy Quest for Stuff app.